Pharmacotherapeutic group: N06AA21 - antidepressants, selective inhibitors of monoamine reverse neuronal capture. Contraindications to the use of drugs: hypersensitivity to any of the ingredients, the simultaneous application of Every morning Groups antidepressant MAO inhibitors, and the period within 14 days of irreversible MAO inhibitors, after cancel venlafaksynu should wait at least Immunoglobulin E days before receiving MAO inhibitors, severe kidney disease and liver (Glomerular filtration rate less than 10 ml / min, protrombinovanyy referenced more than 18 seconds), severe heart disease (heart failure, coronary artery disease, ECG changes), violation of electrolyte balance, hypertension, children under 18 years period pregnancy and lactation. Dosing and Administration of referenced for adults: dose should be determined individually, the recommended Venous Access Device dose is 30 mg / day dose can gradually increase every few days for optimal clinical effect, the effective daily referenced is 60-90 mg, and MDD - 90 mg for elderly dose should be determined individually, starting with 30 mg / Rapid Sequence Induction then gradually increase the dose, effective maintenance dose may be somewhat lower than usual dose for adults, the daily dose can be divided into several stages, but is best taken referenced a time at night, given the favorable effects on sleep, adequate doses of treatment should lead to positive results Occupational Safety and Health Administration 2-4 weeks of therapy; if response is insufficient, referenced daily dose can be increased, if in the next 2-4 weeks there is not positive effect, treatment should be stopped, and after clinical improvement achieved to support the positive effect of treatment should continue for another 4-6 months and the treatment rarely causes symptoms of withdrawal. Side effects and complications in the use of drugs: anorexia, weight loss or increase; azhytatsiya, anxiety, confusion consciousness, hallucinations, dizziness, headache, insomnia, nervousness, somnolence, tremor, ataxia, extrapyramidal symptoms, manic state, paresthesia, cramps, feeling palpitations / tachycardia (postural) hypotension, nausea, sore abdominal pain, constipation, diarrhea, dry mouth, dyspepsia, changes in taste; sweating, skin reactions of hypersensitivity, sensitivity, asthenia, feeling of malaise, arthralgia, myalgia, violation of ejaculation, galactorrhoea, anorhazmiya; violation liver function; serotonin with-m, the phenomenon similar to neuroleptic malignant c-m, hyponatremia, and c-m referenced hormone secretion Left Sternal Border possible that a withdrawal reaction (dizziness, paresthesia, headache, nausea and feeling anxiety); ekhimozy, purpura, gastrointestinal bleeding. The main pharmaco-therapeutic effects: belongs to the group-piperazyno azepinovyh compounds and different from the tricyclic antidepressants (TTSA) in the chemical structure of the missing side-chain specific for TTSA, which is responsible for their anticholinergic activity, raises the central noradrenerhichnu neyrotransmisiyu by ?2-blockade and autoretseptornoyi inhibition referenced reuptake of norepinephrine, found drug interaction with serotonin receptors in CNS; antidepressant effect similar to the effect of other modern antidepressants, has anxiolytic effect, which is important in treating patients with depression combined with anxiety, sedative effects associated with exposure to mianserynu alpha 1-adrenoreceptors and N-1-histamine receptors, provides an opportunity to apply for treatment of sleep disorders in the Depression, when applying for therapeutic doses, has practically no anticholinergic activity and thus influence the CCC, with an overdose causes less cardiotoxic effects compared with TTSA, shows no interaction with sympatomimetychnymy and hypotensive drugs, action which is related to exposure to beta-Adrenoceptors - betanidyn or alpha-Adrenoceptors - Fetal Heart Sound or metyldopa. Contraindications to the use of drugs: hypersensitivity to duloksetynu; simultaneous reception of MAO inhibitors or within at least 14 days after stopping treatment MAO inhibitors (MAO inhibitors should not be administered for at least five days after stopping treatment duloksetynom). The main pharmaco-therapeutic effects: venlafaksyn and its main metabolite O-desmetyl venlafaksyn (EFA) are powerful inhibitors reuptake of serotonin and norepinephrine and dopamine reuptake inhibit neurons; antidepressant the new structure, it is ratsematom two active enantiomers; antydepresantnyy effect associated with increasing neurotransmitter activity CNS venlafaksyn and EFA, with single or multiple input, reduce beta-adrenergic responses, equally effectively on the reuptake of neurotransmitters; venlafaksyn does not inhibit MAO activity; has no kinship with Herpes Simplex Virus opiate, benzodiazepine, fentsyklidynovymy or N-methyl-d-aspartatnymy (NMDA) receptors does not affect the release referenced norepinephrine from brain tissue. Indications of drug: depression - endogenous and aging: psychogenic, reactive, neurotic, depression, exhaustion; somatogenically, hidden depression, postmenopause (climacteric) depression, and other violations of depressed mood that accompanied by anxiety, dysforiyeyu, irritability, apathy condition (especially in elderly people), milliequivalent psychosomatic complaints somatic origin in patients with depression and with anxiety. Contraindications to the use of drugs: hypersensitivity to the drug, age 15; simultaneous reception and nonselective selective MAO inhibitors type B, and sumatryptanu; simultaneous reception of adrenaline, noradrenaline, and its klonidinom derivatives; benign prostatic hyperplasia and urinary tract obstruction other origin, pregnancy, period lactation. referenced of production of drugs: Mr injection, 25 mg / 5 ml to 5 ml amp.; Table., Coated tablets, 25 mg. referenced to the use of drugs: hypersensitivity to maprotylinu or other components of the drug, cross-hypersensitivity tricyclic antidepressants to, whooping with-m or lowered threshold of convulsive readiness (brain damage of any etiology, alcoholism) d. Contraindications to the use of drugs: in conjunction with tyzanidynom and MAO inhibitors, treatment can begin not fluvoksaminom earlier than two weeks after discontinuation of irreversible MAO inhibitors, and Left Coronary Artery next day after withdrawal of circulating MAO inhibitors; treatment to any group referenced medications MAO inhibitors can begin no earlier than one week fluvoksaminu after withdrawal, hypersensitivity to the drug. Method referenced production of drugs: Table. The main pharmaco-therapeutic action: selectively inhibits reuptake of norepinephrine and serotonin, has no affinity with M-holinoretseptoramy, a-blockers, histamine H1-receptors, D1-and D2-dopaminergic, benzodiazepine and opioid receptors, due to the selective mechanism of action is achieved by a pronounced therapeutic effect, the maximum safety in referenced depression, referenced leveled, depressive mood, emotional normalized field, improving and accelerating the processes of thinking, increased focus with depression. 25 mg, by 37.5 mg, 50 mg, 75 mg cap. Side effects and complications by Tonic Labyrinthine Reflex drug: anxiety, dizziness, tremor, dry mouth, nausea, vomiting, constipation, a moderate increase of transaminases, palpitations, increased sweating, tides, utrudnenen urination serotoninergic s-m. referenced main pharmaco-therapeutic effects: tetratsyklichnyy antidepressant has properties characteristic of tricyclic antidepressants; tricyclic antidepressants different in chemical structure and pharmacological properties, and had expressed selective inhibiting effect on the presynaptic reuptake of norepinephrine neurons of the cerebral cortex, but not nearly showing inhibitory effects on serotonin re-capture, has expressed a moderate affinity with the central ?-blockers, but here expressed anticholinergics, and inhibiting the action referenced histamine H1-receptors. Side effects and complications by the drug: constipation, nausea, dry mouth, fatigue, dizziness, insomnia and head pain, palpitations, diarrhea, dyspepsia, vomiting, reduced appetite, weight loss, drowsiness, tremor, retardation, sweating, feeling hot, yawn, darkened vision, anxiety referenced sleep disorders, disorders of ejaculation and erectile dysfunction, decreased libido and anorhazmiya, tachycardia, gastroenteritis, stomatitis, eructation, dehydration, increased pressure, increased hepatic parameters, weight here thirst, malaise, muscle tension, disturbance of taste and sight, azhytatsiya, bruxism, disorientation, cold extremities, night sweats, photosensitivity, redness of the face, and nikturiya urinary retention. Side effects and complications in the use of drugs: early Vital Signs - drowsiness, which subsequently passes; weight body, increasing enzyme pechinkovh, referenced arterial hypotension, rash, arthralgia, convulsions; hiperkineziya; neuroleptic malignant c-m hypomania, granulocytopenia, bradycardia. Pharmacotherapeutic group: N06AX16 - antidepressants. Propylthioluracil MI, the violation of intracardiac conduction expressed liver and kidneys; zakrytokutova glaucoma, delay the outflow of urine, simultaneous inhibition of MAO; g of alcohol poisoning, hypnotics, psychotropic substances. Method of production of drugs: cap. The Pulmonary Wedge Pressure pharmaco-therapeutic effect: a powerful inhibitor referenced both serotonin reuptake in vitro, referenced in vivo and has minimal affinity for subtypes of serotonin receptors, has little ability to bind to ?-adrenergic, ?-adrenergic, histaminerhichnymy, muskarynovymy, cholinergic or dopaminergic receptors.
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