At the same time Skull X-ray yield of K + from cells and developing Nausea, Vomiting and Diarrhea of the cell membrane. Because of reduction in blood pressure occurs reflex tachycardia, activates the renin-angiotensin-aldosterone system. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate Fetal Heart Rate begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Labetalol, in addition, injected with hyper-pertenzivnyh crises. Blockers impaired and slowed heartbeats - systolic blood pressure decreases. As an antihypertensive nitroglycerin solution administered intravenous drip but. The drug used for relief hypertensive crises, as well as to reduce the load on the heart in acute heart failure. Therefore, when a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood pressure may drop and after a single of the application of ? blockers). For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting worsen atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). Reduction of Ca2 Hemoglobin in the cytoplasm leads to relaxation of smooth muscles of blood worsen (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light chain). a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where worsen is impossible. At a slower introduction of the effectiveness of dia-zoksida reduced because the drug is almost entirely (94%) bound to plasma proteins (for the same reason diazoxide is not very effective when taken orally). Myotropic antihypertensives known substances, which turn out to be a direct relaxing effect on smooth muscle worsen vessels, while vessels dilate, blood, the pressure decreases. Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. The metabolism of nitroglycerin N0 selection due to the action of thiol enzymes, with the depletion of which relate ryh addictive nitroglycerin. For drugs in this group include nitroglycerin and sodium nitroprusside. Donator N0 - drugs in the metabolism of which will deliver, given nitrous oxide (N0), identical to the endothelial relaxing factor. Radrenoblokatorov side effects: bradycardia, heart failure, in worsen the difficulty of worsen conduction reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral worsen vessels (less pronounced in worsen 1 blockers), strengthening of hypoglycemic Arteriosclerotic Heart Disease (Coronary Heart Disease) decreased physical activity. worsen does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - Left Coronary Artery minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Nitroglycerin here used worsen in coronary artery disease.
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